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The Big Fantastic Virus Database (BFVD) is a repository of 351,242 protein structures predicted by applying ColabFold to the viral sequence representatives of the UniRef30 clusters. BFVD holds a unique repertoire of protein structures, spanning major viral clades.

Kim R, Levy Karin E, Steinegger M. BFVD - a large repository of predicted viral protein structures Nucleic Acids Research doi: doi.org/10.1093/nar/gkae1119 (2024)

Updates

• 2024-09-04: First distribution of BFVD.
• 2024-11-01: Based on the Logan-MSA, the predicted structures and the metadata were updated.

Availability

• BFVD is browsable with UniProt accessions through website
• BFVD is searchable through Foldseek webserver
• Scripts for BFVD analyses are available at Zenodo
• PDB files of BFVD are also available at Zenodo

Data description

1-bfvd.tar.gz: 351,242 predicted structures of BFVD.
2-bfvd.version: version file.
3-bfvd_foldcompdb.tar.gz: Compressed version of Foldseek database using Foldcomp.
Only 347,481 structures, none of which are discontinuous, were included.
4-bfvd_foldseekdb.tar.gz: Foldseek databse of 351,242 predicted structures of BFVD.
5-bfvd_metadata.tsv: General information of each model.

1. UniRef100: UniRef100 identifier of the sequence
2. model: File name of the predicted protein structure
3. avg_pLDDT: Average pLDDT score of the predicted protein structure
4. pTM: pTM score of the predicted protein structure
5. splitted: Whether the protein sequence of UniRef100 entry was splitted into multiple models
   We splitted the protein sequences if their length are above 1500. (0 = not splitted, 1 = splitted)

6-bfvd_msa.tar: MSAs for each BFVD entries
7-bfvd_taxid.tsv: BFVD entry and their taxonomic identifier.

1. model: File name of the BFVD.
2. taxId: Taxonomy identifier of the protein.
   The protein ID, the portion before the first underscore in model, was used to retrieve the taxonomy ID.

8-bfvd_taxID_rank_scientificname_lineage.tsv: BFVD entry and their taxonomic information.

1. model: File name of the BFVD.
2. taxId: Taxonomy identifier of the protein.
   The protein ID, the portion before the first underscore in model, was used to retrieve the taxonomy ID.
3. rank: rank of the taxonomy.
4. scientific name: scientific name of the corresponding taxonomy identifier.
5. lineage: lineage of the taxonomy.

9-uniref30_2302_virus-rep_mem.tsv: UniRef30 virus clusters.

1. repId: Cluster representatives used for structure prediction
2. memId: Member corresponding to the representative